Collaborative Care treat underlying cause, adequate oxygenation (PaO2 >= 100, PaCO2 35-45, Intubation, Mechanical ventilation), surgery, Drug therapy Mannitol (plasma expansion, osmotic effect, monitor fluid and electrolyte status) Hypertonic saline (Moves water out of cells and into blood, Monitor BP and serum sodium levels), Corticosteroids (Vasogenic edema, Monitor fluid intake, serum sodium and glucose levels, Concurrent antacids, H2 receptor blockers, Proton pump inhibitors), Antiseizure medications, Antipyretics, Sedatives, Analgesics, Barbiturates Nutritional therapy Hypermetabolix and hyper catabolic state increase need for glucose, Enteral or parenteral nutrition, early feeding (within 3 days of injury) Keep patient normovolemic, IV 0.9% NaCl preferred over D5W or 0.45% NaCl