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communication (pathway (Paracrine : short(synaptic), Endocrine :…
communication
pathway
Paracrine : short(synaptic)
Endocrine : long(hormone)
Autocrine：self+others(cell density↗→signals↗→stop)
Contact-Dependant : membrane-bound receptor
Direct Intercellular：cell junction
receptor
GPCR
ligand-gated ion channels
enzyme-linked
ex:hormone
p. kinase
step
signal transduction
relay protein
protein kinase cascade(MAP-kinase)
cell response
receptor activation
apoptosis
role
maintain cell number
eliminate wrong cell
sculpt tissues&organs
pathway
extrinsic：death recepter
mitochondrial：DNA damage
(cytochrome c→apoptosome→caspase)