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AKI (AZOTAEMIA
Hallmark feature (INTRA-RENAL
Renal pathology (RENAL…
AKI
ATN
GENERAL FEATURES
- INJURY & NECROSIS OF RENAL EPITHELIAL CELLS
- NECROTIC CELLS BLOCK TUBULES
- BROWN GRANULAR CASTS IN URINE
ETIOLOGY
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NEPHROTOXIC
TOXIC AGENTS
- CONTRAST DYE
- HEAVY METALS
MEDICATIONS (PAIN+)
- PPIs
- AMINOGLYCOSIDES
- ACEI
- ARB
- IMMUNOSUPPRESSANTS
- NSAIDs
- +ANALGESICS
ACUTE INTERSTITIAL NEPHRITIS
- DRUG INDUCED HSR:
- EOSINOPHILS IN URINE
PRESENTATION
- OLIGURIA
- FEVER
- RASH
- CESSATION OF DRUG RESOLVES PATHOLOGY
- BECAUSE IT'S A HYPERSENSITIVITY REACTION
GLOMERULAR
- PSGN
- RPGN
- ANTI-GBM
- DIABETES MELLITUS
- GOODPASTEURS
- GRANULOMATOSIS C POLYANGIITIS
RENAL PAPILLARY NECROSIS
POSTCARDS
- NECROSIS OF RENAL PAPILLAE
- PRESENTATION:
- GROSS HAEMATURIA
- FLANK PAIN
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CRYSTAL-INDUCED NEPHROPATHY
- URIC ACID/GOUT
- MULTIPLE MYELOMA
PRE-RENAL
URINALYSIS
- SERUM BUN:CR >15
- TUBULAR Fx NOT AFFECTED
- FENa <1%
- URINE OSM >500
- TUBULES ARE CONCENTRATING
AETIOLOGY
- DECR. PERFUSION
- CARDIAC FAILURE
- SEPSIS
- BLOOD LOSS
- DEHYDRATION
- VASCULAR OCCLUSION
POST-RENAL
- OBSTRUCTION (eg. URETERS)
EARLY STAGE
- Incr. tubular pressure
- Tubular fx remains intact
LATE STAGE
- Leads to tubular damage
- Decr. reabsorption of BUN
- Decr. reabsorption of Na+
- Inability to concentrate urine