Signs advanced cancer induration, ulceration, fungation, fixation, teeth mobility, exophytic lesions broad bae w rough surface, ulcerative lesions crater-like w raised, rolled, inruated margins, painless, pain from secondary infection or perineural invasion, suspect & biopsy lesion unknown cause 2+ weeks, carcinoma feature is invasion of CT, hyperchromatism, pleomorphism, keratin pearls, CT chronic inflam infiltrate, well differentiated (grade 1, little keratin production), grade 2 mod differentiated, grade 3 bizarre. Differentiation degree gives prognoses, extent, site, nodes into acc