Case definition: clinical AND lab definitive
Isolation of YF virus and seroconversion
Case Ix: determine likely source
Isolation: avoid contact with mosquitoes until 5 days post onset of illness
Clinical Mx: supportive (Can be a severe illness)
Unimmunised who travelled with the case should be placed under quarantine surveillance for 6 days since travel in YF country. AQIS (Austrailan Quarantine Inspection Service) do this
Defn: unimmunised and traveled with case
OB = 1 case of locally acquired YF
Globally: vaccine is key in response
Routine prev (Aus): require proof of vaccination if arriving from endemic/at-risk region.
Infectious period: after onset fever - 3 to 5 days
Incubation period: 3 - 6 days
Vector-borne illness (flavivirus), aedes aegypti mosquito. Highly effective vaccine available for >12 mo
High-risk countries: south america, africa
3 trasmission cycles: jungle, intermediate and urban. Urban: explosive epidemics when travellers from rural areas introduce viruses into large population centres
Clinical: acute and toxic phase. Acute = fever, muscle pain, backache, headache, LOA, nausea, vomiting. Toxic = jaundice, abdo pain, vomiting, haemorrhage, organ damage.
Current happenings: Brazil had largest outbreak since 1980, declared over in early Sep.