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Lymphatic/Immunity (Immune (Adaptive Response (Sites (MALT(Mucosa assi…

- - - - B cells
        
        Produce diverse antibodies that is activated by and antigen
        
        B memory
        
        Plasma cell
        
        activated B cell
        
        secretes antibodies
        
        Contains Rough ER
        
        B effecter
        
        Matures in blood marrow
    - - T cells(thymocyte)
        
        Communicate c other adaptive cells& destroy cells infected c pathogens
        
        Developed in bone marrow. Matures in thymus
        
        T effector
        
        T memory
    - - Lymphnodes
      - MALT(Mucosa assi lymp tissue
        
        GI tract, breast tissue, lungs, eyes
        
        Peyers Patch
        
        Small intestine
        
        responds to ingested pathogens.
        
        M(microfold) cells
        
        test materials form intestinal lumen then transport to follicles
      - BALT(Bronchus asso lymph tissue)
        
        Bifurcationof bronchi and arteries.
        
        Defense against inhaled pathogens
  - - - Skin
        
        hair, ears, nares, sweat
      - Mucous Membranes
        
        Oral, stomach, saliva
      - Any entry exposed to external environment.
      - Prevents pathogen invasion into body tissue
    - - First line of defense to viruses and some cancers\
      - Cell killing(cytotoxic) granules. (death star)
        
        Fas Ligaud
        
        receptor molecule bind to fas of infected cell.
        
        Perforin
        
        releases perforin on infected cell forming pores which allows entry of granzyme causing apoptosis.
    - - Contains Lysosome
      - ability to ingest and destroy particles or cells. (Phagocytosis)
      - Mast & basophil cells
        
        inflammatory response
      - Complement system
      - Macrophages
        
        pseudopodia
        
        AKA's
        
        Histocytes(connective tissue)
        
        Aveolar macrophages (lungs)
        
        Kupffer (liver)
      - Neutrophil
        
        Response to chemothaxis
      - Monocyte
        
        changes to dendritic cells or macrophages.
  - - - Bone Marrow
        
        hematopoiesis location
      - Thymus
        
        Between sternum and aorta
        
        resolves with age.
    - - Lymphnodes
      - Spleen
        
        "Filter of blood"
        
        removes microbes, materials and dying RBC
        
        Red pulp
        
        Filtration system
        
        Attached to stomach via gastrosplenic ligament
        
        White pulp
        
        T & B cell responses are mounted
      - Tonsils
        
        Develop immunity to common environmental pathogens.
        
        Pharyngeal(adenoid), Palatine, Lingual.
- - - - Afferent vessel (entry)
      - Efferent vessel (exit)
      - Removes debris and pathogens from lymph
    - - Endothelial flap
        
        Prevents back flow
        
        increased pressure opens, decreased closed by filament
      - Lacteals
        
        Within small intestine
        
        absorbs lipids,chyle
    - - larger vessel that drains into duct
    - - Thoracic
        
        receives 75% of fluid
      - Cisterna chyh
        
        beginning of thoracic duct. Received fluid from abd down
      - Right lymph
        
        receives fluid from RUQ and 1/2 of cranium