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Glaucoma Diagnostics (Other (Telemedicine, Nerve functioning test,…
Glaucoma Diagnostics
Other
Telemedicine
Nerve functioning test
Targeted nanoparticle materials
Injectable wireless device to send signal when glaucoma
Vaccine for glaucoma
Muscle test to detect IOP
Stent around nerves to protect from pressure
Devices
Algorithm
Inputs
Biophysical targets
Biochemical targets
Imaging targets
Patient's genetic profile
Population genomics data
Age
Ethnicity
Output
Personalized IOP thresholds
Glaucoma diagnosis
Improvement on current technologies
Pressure
More accurate pressure sensor
Combine current technologies
smaller
share information
faster
simpler
more convenient
Making them easier
Fundus imaging
something to see through eye so dilation isn't necessary
Peripheral vision measurement
VR headset
Embed diagnostic software into games
BCI
Patient
Surgical
Location
Optic nerve
Around optic nerve
Cavity behind eye
Function
Continuous imaging
Protection
Pressure sensing
Type
Sheath
Pressure sensor
Nano-camera
Wearables
Type
Glasses
Contacts
Function
IOP
Aqueous outflow
tear biomarkers
Eye movement
Nighttime monitoring
Where
At optometrist
At home
Biochemical
Biomarkers of glaucoma (optic neuropathy)
snoRNA: compare healthy vs. diseased
Nerve death (apoptosis) indicators
Protein preferentially expressed under elevated IOP (TGF-B1, IL-12p70, SAA, IL-6)
Sample type
Blood
Tissue (biopsy)
Tear
Other ocular fluids
Sample acquisition
Nanobot
Embedded microfluidic assay system
Contact lens
Biopsy
Transduced human cells with viral vector
Fake eyelashes
Eye drop with reporter system
Imaging
Target
Absorbance / density of aqueous humor as a proxy for IOP
Optic nerve (behind the eyes)
Ganglion cells
Glial cells
Pre-apoptotic cells
3D scan of eye
Number of optic nerves / cells
Fundus
Measurement tools
Modalities
Visible light
Other EM frequencies (hyperspectral)
Ultrasound
Devices
Contact lens
Nanobot
Embeded chip
Smartphone
Attachment
OCT Camera
Dedicated camera
VR headset
Glasses
Fake eyelashes
Biophysical
Target
IOP
Aqueous outflow
Aqueous production
Pressure on nerve (rather than IOP)
Using muscle tests to detect pressure
Pressure differential with cerebrospinal fluid (in subarachnoid space)
Pressure differential across lamina
Tools
Contact lens
Nanobot
Imaging
Eye drops
Ex: Change color when IOP too high
Injectable bacteria
Implanted sensors
Awareness/ Accessibility
Target
Public
PSAs
peripheral vision testing app
glaucoma run
fundraising
PCPs discuss risk
suggest/perform tests at glasses store (if eye score too low)
Easy-to-use charts and classifiers
Testing kiosk at pharmacy/lens store
Optometrists
required training
Turbotax-style system
Easy-to-use charts and classifiers
better training
codiagnostic with other diseases
myopia
cataracts
Behavioral
Tools
Glasses
Contact lenses
Search history
Smartphone
Behaviors
Eye movement :
during day
night time
Blinking frequency
Driving pattern (steering input)
Squinting frequency
Search history
Time spent on smartphone
Headaches
Treatments
Idea
Decrease aqueous production
Increase aqueous outflow
Nourishment to increase health of optic neurons
Change eyeball shape / volume
Train eyes to self-control IOP
Transplant or regeneration of optic neurons
Bioavailability
Drug
Eyedrop
Nanodrops to reduce cost
Injectable polymer
(Injectable) optic nerve care/nutrients
Device
Smart contact lens or nanobot
Heat / cold therapy
Continuous drug release
Apply pressure
Ultrasound
Permeates eye
Physical
Eye muscle workout
Eye massages
Biological
Optic nerve transplant
Injectable stem cell therapy
