Please enable JavaScript.

Coggle requires JavaScript to display documents.

Schizophrenia (DSM (Delusional disorder (without hallucinations), Spectrum…

- - - - delusions
      - hallucinations
      - disorganized thinking
      - abnormal motor behavior
      - negative symptoms
        
        aboulia
        
        abscence of willpower
        
        cogntitive problems
        
        attention, memory, executive function, processing speed
- - - - high risk state preceding transition to schiz.
      - Weeks to years
      - First anxiety, depression, social withdrawal
        
        then basic symptoms: disturbances in perception, cognition, expression
        reduced stress tolerance
        
        disorganized speech, sub dignostic positive symptoms
      - Does not always lead to psychotic disorder
    - - unusual thought content
      - impairment of verbal learning/memory
      - suspiciousness and paranoid ideation
      - Low IQ
      - Substance abuse
      - Migrant status
      - isolation
      - poor quality of life
      - comorbidity
      - neurological soft signs
        
        motor/sensory changes provoked by neurodevelopmental abnormalities
  - - - Gene encoding neurexin 1
        
        consistently linked to schiz.
    - - increased exposure/sensitivity to stress
    - - altered glutamatergic transmission
        
        inceased in striatum
        
        decreased in thalamus
        
        drives alteration in dopamine
        
        mesolimbic hyper, mesocortical hypo
    - - lateral ventricle
  - - - dose response
      - Use might be caused by emerging schiz.
      - cannabis could trigger psychosis in vulnarable group
    - - heavy cannabis use causes specific cannabis psychosis
      - cannabis use precipitated schiz. or worsened
      - Difficult to find someone with schiz. who only used cannabis
      - coplex interplay between genetics, environment and stress vulnerability
- - - - ability to perform a skill under optimal conditions
      - Can predict world functioning
      - Independent of positive symptoms, slightly correlate with negative
    - - What patient does in real life
      - influenced by many factors
        
        Positive and negative symptoms
        
        depressed mood
        
        course of illness
        
        cognitive abilities
        
        moderate correlation
        
        social cognition
        
        understand self/other in context of social interaction
        
        Linked to QoL,
        interpesonal relationship, work/personal acheivements
        
        premorbid functioning
        
        family environment
        
        early childhood experience
  - - - study interplay of clinical, neurocognitive and social cognitive domains
    - - psychopathology
      - intelectual level
      - cognition
      - ToM
      - Emotion recognition
      - empathy
      - prior functioning
      - adverse child experiences
      - real world behavior
      - Functional capacity
    - - No correlation beween 2 functioning constructs
      - Significant effect of IQ
        
        several functions
      - empathy and premorbid
        
        minor effect
      - psychopathology significant
      - emotion recognition significant
      - ToM
        
        also effect
      - In sum, results support a divergence between the two constructs of functioning and their underlying components. Functional capacity of
        patients with schizophrenia is mainly related to neurocognitive variables, whereas real-life behaviour, is more complex and requires the
        integrations of different factors including symptoms, with a major role of social cognitive abilities, especially empathy.
- - - - poverty of speech
        blunted affect
    - - amotivation
        asociality
        loss of anticipatory pleasure