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From nutriomics to biomarkers and diet design: exploring the systems…
From nutriomics to biomarkers and diet design: exploring the systems biology approach
Motivation and State-of-the-art
Link diet - health
Generalities role of diet in disease/ health
Trend EU2030 personalised nutrition.
Need of systematic techniques to face the challenge
Omics techniques to analyse interactions diet-disease (nutriomics)
Genralities omics techniques as source of data
Bioinformatics as means to analyse data- Networks - biomarkers
The case of the Atlantic / Mediterranean siet: w3 and polyphenols
Current status of knowledge.
Proteomics / Lipidomics ( others)
Relevant players: proteins / lipids
Counterintuitive effects- combinations of w3 and polyphenols
Need to gain mechanistic knowledge : w3 , polyphenols and their combined effects
From omics to mechanisms in systems medicine and personalised medicine
Generalities reductionist approach disadvantages; emergence of complex behaviours - disease
Systems biology (systems medicine) approach
Our aim - systems nutrition
To explore the possibilities of the systems biology approach towards the identification of early disease biomarkers and subsequent personalised nutrition by means of a relevant case: w3 and polyphenols as critical players to recover from metabolic síndrome related diseases.
Objectives
To achieve our major aim the following sub-objectives are formulated:
To develop models to gain novel insights on the role of w3 and polyphenols and their combination in liver metabolism
To combine proteomics and lipidomics data with modeling to explore liver metabolism dynamics
To use the systems biology approach to identify early disease biomarkers.
Methodology and work-plan
WP2: Experimental desing and data acquisition
WP1: Modeling of liver metabolism under different diets
WP3: Systems biology approach towards early biomarkers and diet design
Group description
(Bio)Process Eng group
Marine products chemistry
Potential Impact
Shift of paradigm in Nutrition research
Possiblity of early -detection of metabolic related diseases
Possibility of personalised nutrition in coherence with personalised medicine