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Osteoporosis (Bone Composition (Collagen (Fibrous Protein, Left handed…
Osteoporosis
Bone Formation
(1)
Reversible
Increase in the number of remodeling cycles
resorption area of trabecular surface increases
increased remodeling space and reduction in degree of demineralization
Irreversible
Imbalance in remodeling with net loss of bone
Remodeling Cycle
(2)
Recruitment of Osteoclasts
Bone Resorption
Reversal
Bone Formation
Osteoblasts synthesize new collagenous organic matrix
End result:
Osteon!
RANKL production inhibited
Decrease in bone resorption
Oc's secrete ephrins
Influence Osteoblast Precursors
Regulated by ratio of RANKL to Osteoprotegrin
Lasts 2-4 weeks
Osteoclasts create cavities
Wnt Protein (6)
Main functions - alterations of bone mass
Mutations in Wnt co-receptor low-density lipoprotein receptor-related protein 5 (LRP5)
linked to alterations in bone mass
renewal of stem cells
stimulation of preosteoblast replication
induction of osteoblastogenesis
inhibition of osteoblast and osteocyte apoptosis
Estrogen
Transcription Factors (11)
Inhibits the resorption of bone by inducing changes in Estrogen-dependent regulating factors
TNF-α
Osteoclast Formation and Reabsorption
TGF-β
Osteoclast activity
Osteoclast apoptosis
RANKL/OPG System
Bone Composition
Collagen
Fibrous Protein
Left handed Helixes
Glycine
Hydroxyproline
matrix proteins
calcium hydroxyapatite crystals
Symptoms
Early Stages
Increased risk of fracture
Back pain due to fractures in vertebrae
Loss of height
Bone Spurs (painful)
Dull pain
Asymptomatic System Disease
Late Stages
Sharp pains that come on suddenly
External tenderness to the area
Treatment Research