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Opioids (History (1500 BC Egypt, greek + rome, arabic world, 16th century…
Opioids
History
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1725 opium wars
--> smoking opium banned in china
--> east indian trading company smuggling
--> war china and britain
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OPICAN study (2001 - 2005)
--> heroin use down
--> perscription opiates soaring
---> easier to get than heroin
--> prescription drugs = most misused / used opioids
--> vancouver + montreal highest heroin users
--> 2005 = canada most use of opioids in world
opioids
--> include story about vietnam veterans as conditioned tolerance or whatever (see body and behavior notes!!)
--> in vietnam all took heroin but they were fine in US without it :3 !!
agonist to endorphine receptors, stimulating them, releasing endorphines ( also blocks dopamin reuptake and binds on dopamine receptors in NAc check rawing in book page 315)
--> reduces pain, stress
--> leads to euphoric state (5 to 15minutes)
-----> followed by 5 to 6 hours of all worries being forgotton and feeling great!
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Intoxication Symptoms:
- leads to euphoric state (5 to 15minutes)
- followed by 5 to6 hours of all worries being forgotton and feeling great !
- slurred speech + drowsiness
- overdose = coma
Withdrawal symptoms:
- anxiety
- restlessness
- muscle aches
- increased sensitivity to pain
- renewed craving to the drug
- fever (in more severe withdrawals)
- nausea and vomiting
---> after 6 hours of injection ( peak is 1 to 3 days)
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Trivia
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collection only within few days of season
--> scraping unripe seedpod until substance leaks
----> this collected = raw opium
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used as
--> pain relieve
--> intestinal disorders (diarrhea)
------> slows down intestine contractions = less diarrhea
--> cough medicine
positive + negative reinforcement
--> positive = feeling high
--> negative = removing pain, feeling bad, or withdrawal symptoms
Types
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oxycodone
--> oxycontin
--> increased 230% between 2001 and 2005 #
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