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Perioperative Pain (Postop # (monitor for analgesic adverse effects…

- - - - opioid naive
      - pre-existing plenary or CVD
      - morbid obesity
      - smoking
- - - - synergistic effects on analgesia
      - each with a lower dose than used alone
      - different MOA
      - opioid sparing
- - - - smoking
      - BZD