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Leukemias (lymphoid (acute: uncontrolled proliferation of immature cells…

- - - - CNS involvement common:
        cranial nerve palsies
        headache &
        vomiting r/t meningeal involvement
      - pain r/t hepato or splenomegaly
        bone pain
    - - chemo
        imatinib mesylate (philly +)
        BMT
        monoclonal antibody therapy
    - - reduced: granulocytes, erythrocytes, plateles
        leukocytes: high or low, with high proportion of immature cells
  - - - lymphadenopathy (can be painful)
        hepatomegaly
        splenomegaly
        anemia/thrombocytopenia
        autoimmune destruction of RBCs/platelets by RES
        "B symptoms:: fever, sweats, weight loss
    - - lymphocytosis (increased lymphocytes)
        early: normal erythrocyte & platelet
        later: decreased erythrocyte & platelet
    - - chemo
        monoclonal antibody
- - - - fever/infection
        weakness
        bleeding
    - - blasts increase by 20%
    - - aggresive chemo
        induction therapy
  - - - asymptomatic
        
        malaise
        
        anorixia
        
        weight loss
        
        confusion, sob r/t leukostasis
        
        enlarged, tender spleen
        
        enlarged liver
    - - increased leukocyte count (>2000,000/mm3)
    - - chemo
        imatinib mesylate (block BCR-ABL protein expression
        BMT