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Urinary (Uraemia: adverse clinical effects that develop as a result of…
Urinary
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Urinalysis
Collection and storage: store for as little time as possible. refidgerate but bring back to room temp before analysis
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Renal function
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Evaluation
solute for measuring GFR: not protein bound, passes freely through the filtration barrier, no secretion or reabsorption, and is neither metabolised or eliminated by extra-renal means
creatinine: endogenous. Constantly broken down from muscle (2%). animals with more muscle or those fed more meat will have increased creatinine
Renal dysfunction may be detected by repeat measurements of creatinine. Critical difference is 35μmol/L
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Incontinence
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USMI: urethral sphincter Mechanism incompetence - continent when alert but incontinent when asleep or recumbent
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Glomerular damage/disease: proteinuria, hypoalbuminaemia, hypercholesterolemia (loss of urinary lipse)
To differentiate: Renal tubular acidosis - characterised by hyperchloremic metabolic acidosis in the presence of normal GFR # #