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DRUGS !!! :lock: (Carbamazepine (ADRS :explode: (acute intoxication…
DRUGS !!! :lock:
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Phenytoin
- Block Na+
- decrease Glutmate
- Enhance GABA
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BZDs& Barbs
activiation of GABA receptor , decrease excitability
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Valproic ACid
1. Inhibit Na+ 2.Inhibit Ca++
- Inc. GABA Content in brain
:check: Inhibit GABA trasaminase
:check:Succinic semi-aldehyde dehydrogenase
:check: Stimulate the activity of GABA synthesis Enzyme (glutamic acid decarboxylase )
4.Inhibit Glutamergic transmission by blocking NMDA Receptors
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