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Tissue Renewal (Cell Cycle (Checkpoints (p53 dependent mechanisms (Delay…

- - - - EGF=Epidermal Growth Factor
      - TGF- α = Transformaing Growth Factor α
      - HGF=Hepatocyte Growth Factor
      - PDGF=Platelet-Derived Growth Factor
      - VEGF=Vascular Endothelial Growth Factor
      - FGF=Fibroblast Growth Factor
      - TGF-β = Transforming Growth Factor β
      - Cytokines
  - - - Restriction point
    - - Delay cycle and trigger repair
      - Apoptosis
      - Senesence
- - - - residual cells
      - tissue stem cells
      - Compensatory growth
        
        hyperplasia
        
        哺乳類
    - - 肝臟
        
        paracrine effects
        
        HGF, IL-6
  - - - 嚴重傷害
      - 持續傷害
      - 無法完全restitution
      - Fibrosis
        
        collagen嚴重deposition
        
        TGF-β
        
        Chronic inflammation
        
        Infarction(梗塞)
      - 有機化(Organization)
        
        Inflammatory exudate
        
        造成沾黏
  - - - clot
    - - Granulation tissue
        
        chronic inflammation
        
        Hallmark of tissue repair
    - - Tissue remodeling
  - - - 乾淨無疤
    - - 骯髒有疤
        
        granulation tissue
        
        攣縮(contracture)
- - - - cytokines
      - chemokines
- - - - 肺癌
      - 大腸癌
    - - 乳癌
  - - - 舊有衍生
        
        Vasodilation
        
        NO
        
        Degradation
        
        basement membrane
        
        Migration
        
        Proliferation
        
        Maturation
        
        Recruitment
        
        Suppression
      - EPCs=Endothelial Precursor Cells
    - - 無中生有
  - - - invasion
      - metastasis
    - - Fibrosis
    - - IL-17-producing T cells
  - - - TNF and IL-1
        
        傷口治癒
      - TNF and IL-6
        
        肝臟再生
- - - - 上皮細胞
      - 骨髓
  - - - 淋巴球
      - 子宮、消化道平滑肌
      - 肝臟細胞
  - - - 中樞神經
      - 骨骼肌、心肌
- - - - Embryonic stem cells
        
        Repopulate or construct
        
        Introducing and functionally integrating
        
        Immunologic rejection (HLA)
      - iPS cells=Induced pluripotent stem cells
        
        Reproductive cloning
        
        但會產生oncogenes
    - - Tissue stem cells
        
        niche
        
        組成 mesenchymal cells 和 endothelial cells
        
        adult stem cell 密集處
        
        adult/somatic stem cell
        
        labile tissues 和 stable tissues 裡面
        
        Transit amplifying cells
        
        Progenitor cells
        
        Transdifferentiation
  - - - HSC=Hematopoietic stem cells
        
        臍帶血
        
        peripheral blood
        
        注射cytokine取得
      - MSC=Marrow stromal cells=Mesenchymal stem cells
        
        受傷嚴重才有
    - - Oval cells
        
        bipotential progenitors
        
        在肝臟再生受阻時活化
        
        惡性腫瘤
      - canals of Hering
    - - Wnt pathway (+)
      - bone morphogenetic protein (BMP) system (-)
- - - - 有
        
        大部分growth factor
      - 無
    - - 在nucleus
  - - - Heterodimerization
        
        最快
      - Phosphorylation
      - Release of inhibition
      - Release from membranes
- - - - 腹部手術
    - - Inadequate vascularization