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Lung Cancer (Non-Small Cell (Squamous Cell (Central -- hilar mass from…
Lung Cancer
Non-Small Cell
Fast Facts
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Not localized, Rx = palliative chemo, XRT
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Multiple mutations (EGFR, ALK, ROS-1)
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Adenocarcinoma
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Paraneoplastic Synd = Hypertrophic Pulmonary Osteoarthropathy -- symmetric polyarthritis and proliferative periostitis of long bones
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Bronchial Carcinoid
Great prognosis, rare mets
Symps = flushing, diarrhea, wheezing. (b/o mass effect or carcinoid synd)
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Small Cell
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SCLC
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Small "blue" malignant cells ~2x lymphocyte size w/ sparse cytoplasm, finely dispersed chromatin, no distinct nucleoli
Paraneoplastic Synds
Cushing's -- excess steroids, "moon face", wt gain
SIADH -- low Na, dizziness
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Rx
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High relapse rate in 1-2 yrs, refractive to treatment
CD56, Chromogranin, Synaptophysin IHC staining (neuroendocrine origin)
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