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Thesis Defense (Chapter 2 (Result 1 Hematological cancer cell line screen,…

- - - - Structure
        
        MANEC domain
        
        Kunitz Domain 1
        
        LDLR domain
        
        Kunitz domain 2
        
        Transmembrane domain
    - - Structure
        
        Kunitz domain 1
        
        Kunitz domain 2
      - Glycosylation
- - - - Pre-B cell
        
        B cell
        
        Plasma Cell
        
        Memory B cell
  - - - Follicular Lymphoma
      - Marginal zone lymphoma
      - Chronic Lymphocytic leukemia
    - - DLBCL
        
        Germinal Center B cell
        
        Activated B cells
        
        Mutation
        
        29% β2-microglobulin gene mutation for circulating T lymphocytes recognition
        
        21% CD58 gene inactivation for NK cell recognition
        
        PD-1 and PD-L1
        
        MHC class II transactivator CIITA fused to PD-L1 or PD-L2, result in HLA-DR expression decrease
        
        Cytokines
        
        CCL22
        
        CCL17
        
        GAL-1
        
        TGFβ
        
        Immunosuppressive cells
        
        M2 macrophage
        
        CD68
        
        Improved overall survival
        
        Rituximab may alter the function of TAM from assisting to anti
        
        Regulatory T cells
        
        Exhausted T cells
        
        Serum IL-6, IL-8, IL-10 Link Title
      - Mantle cell lymphoma
        
        Molecular hallmark
        
        t(11;14) translocation
        
        Constitutive expression of Cyclin D1
        
        Cell cycle deregulation
        
        Extranodal dissemination
        
        VLA-4
        
        CCR7
        
        CXCR5
        
        CXCR4
        
        Adhesion to stromal elements
        
        IL-6 secretion
        
        JAK/STAT3
        
        PI3K/Akt
        
        CD4+CD25+FoxP3+ Treg
        
        Reduction of anti-tumor cytotyxicity
        
        PD-L1
        
        Impaired T-cell proliferation
        
        PTEN inactivation
        
        BCR
        
        Syk
        
        Btk
        
        PI3k-Akt
        
        BCR-mediated adhesion
        
        Anti-apoptosis
      - Hodgkin lymphoma
  - - - Btk
        
        PIP3
        
        Akt
        
        GSK3
        
        MDM2
        
        RAF
        
        MEK1/2
        
        ERK1/2
        
        AP-1
        
        Bcl-XL
        
        PKCβ
        
        CARD11/BCL-10/MALT1
        
        IKKγ/IKKα/IKKβ
    - - STAT3
    - - NIK/RIP/TAK1
        
        IKK
        
        IkB-a
        
        NF-kB
        
        Bcl2