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Animal Model Reflecting Heart Failure With Preserved Ejection Fraction…
Animal Model Reflecting Heart Failure With Preserved Ejection Fraction (HFpEF)
Reduced Ejection Fraction (Systolic HF)
Chamber dilation
Preserved EF (Diastolic HF)
Chamber hytpertrophy
Not filling with enough blood/not pushing the amount of blood necessary
Keywords
Preload dependent
Animal models
Heart failure with preserved ejection fraction
Diastolic dysfunction
Model to reflect
Histopathological findings
microscopic examination of tissue to study disease
Hemodynamic changes
relating to the flow of blood, circulatory system is controlled by homeostatic mechanisms
Biomarker
BNP (B type natriuretic peptide) produced by heart ventricles in response to increased mechanical load and wall stretch
Echocardiography marker
sonogram of the heart
Cardiac reserve
rate at which heart pumps blood and its max cap for pumping blood
Macro- and microvascular function
pulmonary physiology
immune regulation
oxygen utilization
renal function
comorbidities
diabetes
metabolic syndrome
chronic kidney disease
In vivo animal model
large animals
can be used to test drug substances