Monamine oxidase
reaction: monoamine + O2 + H2O = aldehyde + H2O2 + Nh3
Constantly active to metabolise neurotransmitters and related
Additional source of H2O2
Outer mitochondrial membrane
inhibitors suggested as treatments for neurodegenerative diseases
deaminate -5Ht, histamine, catchelomaines, dopamine, adrenalin, noradrenaline
MAOA and MAOB
regional differences in levels
expressed in glia
cell bodies and nerve terminals
may have a role in protecting brain from amines
toxicity of the reactive aldehyde is a coupled system depends on aldehyde dehydrogenase as well
link to cardiolipin
f;avin
activity seems to rise with age
linked to metabolism of xenobiotic amines
MOAA can lower membrane potential link to apoptosis
may have off-target effects
reduced and by substrate binds O2- generates H2o2