Monamine oxidase

reaction: monoamine + O2 + H2O = aldehyde + H2O2 + Nh3

Constantly active to metabolise neurotransmitters and related

Additional source of H2O2

Outer mitochondrial membrane

inhibitors suggested as treatments for neurodegenerative diseases

deaminate -5Ht, histamine, catchelomaines, dopamine, adrenalin, noradrenaline

MAOA and MAOB

regional differences in levels

expressed in glia

cell bodies and nerve terminals

may have a role in protecting brain from amines

toxicity of the reactive aldehyde is a coupled system depends on aldehyde dehydrogenase as well

link to cardiolipin

f;avin

activity seems to rise with age

linked to metabolism of xenobiotic amines

MOAA can lower membrane potential link to apoptosis

may have off-target effects

reduced and by substrate binds O2- generates H2o2