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Monamine oxidase (reaction: monoamine + O2 + H2O = aldehyde + H2O2 + Nh3,…
Monamine oxidase
reaction: monoamine + O2 + H2O = aldehyde + H2O2 + Nh3
Constantly active to metabolise neurotransmitters and related
Additional source of H2O2
deaminate -5Ht, histamine, catchelomaines, dopamine, adrenalin, noradrenaline
MAOA and MAOB
toxicity of the reactive aldehyde is a coupled system depends on aldehyde dehydrogenase as well
link to cardiolipin
f;avin
reduced and by substrate binds O2- generates H2o2
Outer mitochondrial membrane
cell bodies and nerve terminals
MOAA can lower membrane potential link to apoptosis
inhibitors suggested as treatments for neurodegenerative diseases
may have off-target effects
may have a role in protecting brain from amines
linked to metabolism of xenobiotic amines
regional differences in levels
expressed in glia
activity seems to rise with age