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L17 Urea Cycle & Amino Acid Synthesis (Making Urea: 1N from NH3 this…

- - - - Effects of TH
        
        Half life of T4 is 7 days, T3= 1 day
        
        Response-rate to changes in TH: slow
        ~ physiological response to ⇈s may not be evident for several days, whereas ⇊s not evident or up to a week due to 1/2 life of T4
        
        Regulates body's rate of O2 consumption & E expenditure(@ rest)
        
        metabolism: particualarly glucose utilisation & storage (later)
        
        heart rate: ⇈s & force of contraction higher
        
        Vasodilation: ⇈s:- causes greater loss of body heat
        
        CNS: Abnormal lvls of TH- nervousness, anxiety, depression etc
      - Clinical imp of Iodine in Diet
        
        Continual supply of iodine essential for continued T3 & T4 to be low in circ, can cause goiter
        
        Ability of enlarged thyroid gland to prod T3 & T4 depends upon severity of iodine deficiency
        
        Most developed nations dd iodine to salt to reduce cases of goiter