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L15 Amino Acid Catabolism (Prot reqs ∆ throughout life Prot synth…

- - - - Phase 1
        
        the 17 aa tht liver can catabolise
        
        remove N (𝜶-amino) from aa
        
        aa - NH3 = 𝜶-keto acid
        
        18/20 aa undergo trans(de)amination
        
        2/20 (Lys, Thr) deamination
      - Phase 2
        
        𝜶-keto acid metabolised
        
        ∴carbon skeleton can enter metabolic pathways:
        ~ gluconeogenesis
        ~ ketogenesis
        ~ or, CO2 + H2O
- - - - Other tissues
        
        Glutamate → glutamyl phosphate → Glutamine
      - Liver mitochondria:
        
        Glutamine → Glutamate