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Basic Virology (part 1) (classification and naming (structure, biochemical…
Basic Virology (part 1)
definition and property
filterable agents
DNA/RNA+protein coat(capsid)
+/- outer lipoprotein membrane(envelope)
obligate intracellular parasites
reproduce assembly
structure
enveloped virus
nucleocapsid=naked capsid virus
DNA/RNA
structural protein
enzymes and nucleic acid binding protein
glycoproteins and membrane
size
20~300nm
shape
complex viruses
Poxvirus(痘病毒)
Bacteriophage
enveloped viruses
Mump virus(腮腺炎病毒)
Herpes virus(皰疹病毒)
Rhabdovirus(棒狀病毒)
HIV
naked viruses
Adenovirus
Papillomavirus
classification and naming
structure
biochemical characteristics
disease
means of transmission
host cell(range)
tissue of organ(tropism)
DNA virus
enveloped
ds DNA
痘病毒科(Poxviridae)
疱疹病毒科(Herpesviridae)
partial ds c
肝DNA病毒科(Hepadnaviridae)
naked capsid
c
腫瘤病毒科(Papovaviridae)
ds
腺病毒科(Adenoviridae)
ss
小病毒科(Parvoviridae)
RNA virus
enveloped
+ss RNA
披蓋病毒科(Togaviridae)
黃病毒科(Flaviviridae)
冠狀病毒科(Coronaviridae)
-ss RNA
桿狀病毒科(Rhabdoviridae)
絲狀病毒科(Filoviridae)
正黏液病毒科(Orthomyxoviridae)
副黏液病毒科(Paramyxoviridae)
本雅病毒科(Bunyaviridae)
沙狀病毒科(Arenaviridae)
+ss RNA(via DNA)
反轉錄病毒科(Retroviridae)
naked capsid
+ss RNA
小核醣核酸病毒科(Picornaviridae)
諾羅病毒(Norovirus)
ds(+/-)RNA
呼腸孤病毒科(Reoviridae)
viral protein
capsid
protein coat
capsomer
icosahedral or helical
enveloped virus
envelope(lipoprotein membrane)
lipid
host cell
protein
virus-specific
matrix protein
capsid
envelope
instability
heat
detergents
lipid solvent
capsid virus vs. enveloped virus
Atypical viruslike agent
defective virus
HDV
pseudovirion
gene therapy:viral vector
host DNA+viral protein
viroid
circular RNA
plant disease
prion
Mad Cow disease
Creutzfeldt-Jakob disease
Kuru disease