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Other Liver Disorders (Haemochromotosis (Complications: (Ascites, Impaired…
Other Liver Disorders
Wilson's Disease
Copper accumulates in carious tissues:
Liver
Brain
Cornea
Kidneys
Impaired biliary copper excretion
Pt presentation:
Acute hepatits OR
Fulimant hepatitis OR
Chronic active hepatitis and
Neuropsychiatric symptoms
Treatment
Zinc supplementation
Copper chelating agents
Haemochromotosis
Pt absorbs excessive Fe from GIT
May store 20-30g compared w 0.3-0.8 in healthy individuals
Diagnosis
Inc transferrin saturation(>45%) and ferritin (2 times more than normal
Life expectancy is normal if phlebotomy is initiated before onset of cirrhosis
Complications:
Ascites
Impaired synthetic hepatic function
Oesophageal bleeding
Abnormal skin pigmentation
Hepatomegaly
Hypogonadism
Glucose intolerance
Hepatocellular carcinoma