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Fulminant Hepatitis (Complications (Hepatic encephalopathy (within 2-8 wks…
Fulminant Hepatitis
What is it?
Rare syndrome of massive necrosis of liver and a decrease in liver size - acute yellow atrophy
Caused by?
Viral hepatitis (~75%)
Chemical toxicity
Other
Wilson's disease
Pregnancy
Malignancies
Complications
Hepatic encephalopathy (within 2-8 wks of illness onset)
coagulopathy and bleeding
CVD abnormalities
renal failure
pulmonary complications
acid-base disturbances
electrolyte imbalances
sepsis
pancreatitis
cerebral oedema
Diagnosis
Liver function tests
PT/INR tests
Clinical evaluation
Mental disturbances
Jaundice
Treatment
Oral nucleosides or nucleotide analogs
Liver transplant
Prognosis
Children have better outcomes
Survival in adults uncommon without transplant