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Connective tissue (extracellular matrix (ground substance…

- - - - major fiber(28 types)
      - histological features
        
        eosinophilic
        
        HE stain
        
        aniline blue-positive
        
        Mallory's stain
        
        light green-positive
        
        Masson's stain
      - structure
        
        (collagen proteins)~(fibrils)~(fiber)
      - classes
        
        fibrillar collagen
        
        type I
        
        90% of body collagen
        
        skin,fascia,tendon,ligament,bone matrix
        
        type II
        
        cartilage matrix
        
        type III
        
        reticular fiber
        
        type V
        
        initiate type I assembly
        
        type XI
        
        cartilage matrix
        
        FACITs=fibril-associate collagens with interrupted triple helixes
        
        type IX
        
        cartilage
        
        hexagonal network-forming collagen
        
        transmembrane collagen
        
        type XVII
        
        hemidesmosome
        
        basement membrane-forming collagen
        
        type IV
        
        basement membrane
        
        type VII
        
        anchoring fibril
        
        multiplexins
      - biosynthesis
        
        intracelluclar synthesis
        
        rER
        
        vitamin c
        
        Scurvy
        
        glycosylation
        
        triple helix(procollagen)
        
        exocytosis
        
        extracellular synthesis
        
        procollagen proteinase
        
        cut N and C domains
        
        fibrillogenesis
        
        covalent cross-linking
      - degradation
        
        proteolytic degradation
        
        MMPs=matrix metalloproteinases
        
        phagocytotic degradation
        
        macrophage
    - - synthesized by
        
        fibroblast
        
        smooth muscle cell
        
        chondrocyte
        
        in elastic cartilage
      - form
        
        elastic ligament
        
        elastic lamella
      - histological features
        
        resorcin fuchsin
        
        orcein
        
        aldehyde fuchsin
      - elastogenesis
        
        elastin
        
        desmosine
    - - type III collagen fiber
        
        tissue maturity
      - argyrophilic
        
        silver impregnation(black)
      - form the frame work
        
        lymph nodes
        
        liver
        
        spleen
        
        capsule of organ
        
        external or basal lamina
        
        embryonic tissue
        
        wound healing
- - - - fine collagen fiber
      - spindle-shaped cell
    - - ground substance
      - spindle-shaped cell
  - - - loose(areolar) CNT
        
        more ground substance
        
        lamina propia=lamina propria mucosae
      - dense CNT
        
        irregular
        
        dermis of skin
        
        papillary layer(上)
        
        Meissner tactile corpuscles
        
        reticular layer(下)
        
        Langer's lines
        
        皺紋
        
        dermal modification
        
        friction ridge
        
        cleavage(Langer's) lines
        
        flexure lines
        
        skin circulation
        
        glomus body(血管球體)
        
        neuromyoarterial receptor(動脈肌神經受器)
        
        skin repair
        
        epidermis repair
        
        scab formation
        
        dermis repair
        
        granulation tissue
        
        myofibroblast
        
        estimating burns
        
        blister
        
        submucosa of GI tract
        
        regular
        
        tendon
        
        fibroblast
        
        coarse collagen fiber
        
        ligament
        
        elastic ligament(yellow ligament)
        
        ligamentum flavum
        
        ligamentum nuchae(nuchal ligament)
        
        aponeuroses
- - - - form (3 types fibers)+(ground substance)
      - activated
        
        repairing
        
        myofibroblast
        
        growth
        
        euchromatic nucleus+prominent nucleoli+basophilic cytoplasm
    - - white adipocyte(unilocular)
      - brown adipocyte(multilocular)
    - - histiocyte
      - derived from monocyte
      - vital stain
        
        trypan blue
        
        mononuclear phagocyte system
      - APCs=antigen-presenting cells
    - - from basophil
      - cytoplasmic granules
        
        hypersensitivity/anaphylaxis
      - metachromasia
        
        heparin/histamine 藍色太強轉成紅色
  - - - from B lymphocyte
      - eccentric cartwheel-appearance (車輪狀)
      - negative Golgi area