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Liver function overview (Blood sources (Portal vein (2/3 blood supply,…
Liver function overview
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CHO metabolism
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Gluconeogenesis (from precursors eg lactic acid, AA'a, intermediates from TCA cycle)
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Protein metabolism
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Forms serum proteins eg albumin, transferrin, lipoproteins, globulins
Formation of clotting factors, fibrinogen, prothrombin
Fat metabolism
Synthesises and hydrolyses TGL, Chol, lipoproteins and phospholipids
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Storage & conversion
Storage, activation transport of many vits & mins (fat solubles,B12, Fe, Zn, Cu, Mg)
Produces protein that transports: Vit A, Fe, Zn, Cu
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Bile
Stored in gall bladder, released into duodenum when fat enters
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Formed in liver cells, exits through bile ducts into common bile duct
Detoxification
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Ammonia to urea by the liver - 75% excreted by kidneys, remainder back to GIT
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