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Musculoskeletal (Clinical Pathology (Creatine Kinase - leakage enzyme…

- - - - skeletal muscle
      - myocardium
      - brain
      - prolonged recumbency
      - IM injections
      - myopathies
    - - lipaemia may increase concentrations
      - haemolysis = increase (since RBC contain CK)
      - Icterus - severe may increase
- - - - Chondodysplasia - abnormality of growth plate
      - Osteogenesis imperfecta - defect in formation of collagen type 1
      - Angular limb deformities caused by asymmetrical lesion involving the growth plate causing abnormal endochondral ossification.
        
        Valgus - lateral deviation
        
        Vargus - medial deviation
      - Feline physeal dysplasia - often bilateral, male, overweight cats. Get dysplasia of the entire physis
      - Disorders of OCL resorption
        
        osteopetrosis - bones show accumulation of traberculae with retention of mineralised cartilage and thin cortical bone
        
        inherited
        
        infectious - growth retardation lattice
        
        Toxic - lead
    - - internal - remodelling
      - external - fracture
    - - Osteoperosis/ osteopaenia
        
        most common bone disease in animals
        
        Loss of bone mass
        
        Ca deficiency - malnutrition or starvation
        
        growing animals - longditudinal growth is retarded
        
        growth resumes when diet is corrected - will see growth arrest lines