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Embryo (Sperm hit membrane and trigger acrosome to breakdown and release…

- - - - Secondary oocyte (egg) completes second meiotic division leads to formation of mature oocyte (ovum) forming 1 polar body and 1 female pronucleus
        
        Sperm injected Nucleus, Tail, and other organelles into cytoplasm
        
        Female and Male
        DNA undergoes replication
        
        Male and Female Pronuclei dissolve (46 total chromosomes) - spindle forms - chromosomes line up on metaphase plate
        
        Zygote becomes 2-Cell embryo via cytokinesis. Each cell in the egg is called a blastomere. Cells are totipotent.
        
        Each blastomere divides and you get 4 total. Cells are starting to flatten on each other.
        
        1 more item...
- - - - Noggin is able to bind up enough BMP4 to prevent growth and bud formation. But only in that one area with the white X. Leads to bud bifurcation. Happens 2^23 times.
    - - When you stain lung buds you only see it at the terminal ends of them.
- - - - Vasculaturization of hypertrophic region needed for invasion by osteoblasts. These osteoblasts secrete Type 1 Collagen and mineral matrices which from a primary spongiosa. Primary spongiosa becomes the Primary Ossifcation Center (POC)
        
        POC grows as the 2 epiphyses move in either direction by proliferating chondrocytes. A bone collar forms around the diaphysis.
        
        At birth, there are growth plates (epiphyseal cartilage plates) between the epiphysis and proliferating chondrocytes of the diaphysis. Ossification of the growth plate happens in late teens.
- - - - 1st hepatic colonization occurs where mesoderm cells migrate to the liver. There are definitive hematopoietic stem cells (dHSCs) populating the liver. d23
        
        Arterial clusters (angiogenic cell clusters/blood islands) begin to fuse to make capillaries, vessels and blood. d27
        
        Second hepatic colonization as more mesodermal cells colonize to create more blood vessels in the liver. d30
        
        Bone marrow colonization. dHSCs migrate to the long bone marrow and become definitive hematopoietic stem cells. these cells give rise to multipotential (progentior) stem cells. They can become myeloid or lymphoid progenitor cells. wk10 Bone marrow development sites. Bone marrow is made in the bones at the places shaded in blue.