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Presentation (Pharmacokinetics (math) (Basic (Cp plasma concentration,…

- - - - Morphine
        
        Date: 6000 BC - 1804 -1853 -1954
        
        Pics: opium, formula, hypodermic needle
        
        Orally: side effects, history
      - Penicilinum
        
        Dates: 1928 - 1938 - 1942
        
        Fleming - Formula - Synthesis
    - - Ranitidine
        
        Idea: Mechanism
        
        https://en.wikipedia.org/wiki/Cimetidine
        
        Formula - Variants - Receptor - Stomack acid
  - - - Phase I: 20 -100. Safety, tolerability
      - Phase II: 100 - 500. Dosing, scheme
      - Phase III: 300 - 3000. Safety and eficacy conformation
      - Phase IV
- - - - Absorption
        
        Salt factor
        
        LogP
        
        Bioavailability
      - Distribution
        
        Compartments model
        
        Binding to macromolecules
      - Metabolism
      - Elimination
        
        Константа вивільнення
        
        Час напіввивільнення