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URINARY SYSTEM (URINE COMPOSITON (PHYSICAL CHARACTERISTICS (COLOUR &…
URINARY SYSTEM
KEY STRUCTURES
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Homeostatic balance <-> fluid reservoir volume & composition regulation, primarily BLOOD (i.e. blood pressure & volume
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RENAL ANATOMY
Renal Hilium: Where numerous blood vessels, nerves pass
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NEPHRON FUNCTION
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NEPHRON COMPONENTS
RENAL CORPUSCLE
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GLOMERULUS - whitish, network of capillaries (beginning at nephron). 1st filtration stage. Blood plasma filtered through capillaries of glomerulus. Afferent arteriole (high pressure/resistance) -> blood -> Efferent arteriole. Forced out -> Gloerular capsule
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COLLECTING DUCTS - ROLE
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H2O reabsorption through AQUAPORINS (water channels selectively conduct H2O, in & out of phospholipid bilayer; prevents passage of ions & other solutes)
Fused together for urine delivery through renal papillae -> minor calyces = kidney chambers through urine passes
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FILTRATE VS. URINE?
FILTRATE = BLOOD PLASMA WITHOUT BLOOD PROTEINS; through collecting ducts: H2O, nutrients, and essential ions lost. URINE = FILTRATE EXIT INTO COLLECTING DUCTS -> CALYCES
FLUID COMPARTMENTS
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Extracellular fluid (ECF) 15 L or 1/3 -> plasma, interstitial space (other ECF: lymph, CSF humours, serous fluid & gastrointestinal secretions)
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URINE COMPOSITON
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PHYSICAL CHARACTERISTICS
COLOUR & TRANSPARENCY: Clear, pale to deep-yellow
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pH: Slightly acidic (~6, from 4.5-8.0)
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Na+ ROLE & REGULATION
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Na+ reabsorption: 65% REABSORPTION IN PCT, 25% REABSORPTION IN LOOPS OF HENLE
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K+ ROLE & REGULATION
Affects RMP in neurons, muscle cells (especially cardiac muscle)
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