Please enable JavaScript.
Coggle requires JavaScript to display documents.
Signal Transduction, Membrane Receptors, Second Messengers, &…
Signal Transduction, Membrane Receptors, Second Messengers, & Regulation of Gene Expression
external
message
internal
physical
chemical
signaling
process
(1) Reception (2) Transduction (3) Response
amplification
agonist-->second messenger-->effector system
Second messenger
small, nonprotein, water-soluble molecules or ions
cAMP
#
Ca2+、DAG、IP3
cGMP
arachidonic acids（Eicosanoid）
directed
arachidonic acids
Lipoxygenase pathway
Epoxygenase pathway
Cyclooxygenase(COX) pathway
indirected
#
termination/inactivation
category
physical
Synaptic
Contact-dependent
chemical
Autocrine
Paracrine
Endocrine
Membrane receptor
Receptor specificity
Cell surface receptor<-->hydrophilic ligand
Ligan-gated Ion channel
GPCRs
Enzyme-linked
w/o
enzyme activity domain
intracellular receptors<>hydrophobic ligand
Regulation of Gene Expression
Signaling pathways
cell-surface receptor
Growth factor-mediated
catalytic receptor-->small G protein-->Ras-->
JAK-mediated
catalytic receptor-->STATs-->
cAMP-mediated
GPCR-->CRE and CREBP-->
intracellular
location
cell surface receptor
nucleus
response
hormone-receptor complex <>transcription factor--> on/off
Post-translational modification of histone tails
location
lysine (K)、arginine (R)和 serine (S) (有–OH 基)
modification
:acetylation、methylation、phosphorylation、ubiquitination