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CONCEPT OF THE GENE (General knowledge (Genome organisation (Prokaryote…
CONCEPT OF THE GENE
General knowledge
Central Dogma of molecular biology :arrow_right: Genotype is the heritable factor that determines Phenotype
Modern understanding :arrow_right: Gene came through observation of inheritable components of phenotype
:point_right: internal cellular chemistry :arrow_right: Enzyme function :arrow_right:Protein structure :arrow_right: Aminoacid sequence :arrow_right: DNA sequence
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Gene Organisation
Gene is a locatable region :couple: associated with regulatory regions, transcribed regions, and other functional sequence regions
Regulatory sequence
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Terminators
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Intrinsic :arrow_right: Termination site on template DNA consists of G-C rich sequences :arrow_right: hairpin loop formation
rho factor (hexametric protein) binds to RNA at rut site :arrow_right: pulls RNA away from RNA polymerase
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Protein coding region
Found by Sharp when viral DNA hybridised with mRNA (during trancription) :arrow_right: there were loop formation in DNA strand
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the different in length btwn RNA and DNA :point_right: suggest that some transcribed regions are cut off
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Intron :arrow_right: non coding intervening sequences (forming a loop during transcription) :!!:many in eukaryote
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