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CONCEPT OF THE GENE (General knowledge (Genome organisation (Prokaryote…

- - - - single circular chromosome
      - lacks basic protein (eg: histone)
      - lies in nucleoid region of cytoplasm
    - - DNA associated with histones
      - very condensed chromosomes
- - - - RNA polymerase binds to for trancription initiation :arrow_right: DNA becomes open complex
      - specific region for specific RNA polymerase :arrow_right: selective gene expression
      - Transcription factors recognise sequence in promoter :arrow_right: RNA polymerase binds
    - - Specific for transcription stops :arrow_right: for transcription termination
      - Intrinsic :arrow_right: Termination site on template DNA consists of G-C rich sequences :arrow_right: hairpin loop formation
      - rho factor (hexametric protein) binds to RNA at rut site :arrow_right: pulls RNA away from RNA polymerase
  - - - :point_right: there were transcribed region and non-transcribed region
      - the different in length btwn RNA and DNA :point_right: suggest that some transcribed regions are cut off
    - - spliced out off RNA by spliceosome
- - - - Precursor :arrow_right: Ornithine :arrow_right: Citrulline :arrow_right: Arginine
    - - :point_right::skin-tone-4: 3 mutations arg-1, arg-2, arg-3
      - The mutants are incapable of synthesizing essential cellular component without addition of organic nutrients