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Anticoagulants anti-platelet (Coagulation (Intrinsic (Factor 8 activates…
Anticoagulants anti-platelet
Thrombus formation
Direct thrombin inhibitors
Causes
Decreeased blood flow
AF
Heart faliure
Blood stasis
Change endothelial suface
MI, prosthetic heart valve
infection
atherosclerosis, inflammation,
Increased blood coagubility
pregnancy, infection
Blood abnormanility
Clotting
Clot disollution
Mechanism
Homeostatic pathway
formation of clot held together by strands of fibrin
alternative stimulus or damage to lining
interaction clotting factors that convert fibrinogen into insoluble fibrin
Forms a clot
Coagulation
Excessive
Intrinsic
Factor 8 activates factor 10 which activates normal pathway to form fibrin
after conversion to factor 10 in both pathways, prothrombin to thrombin. WHich causes fibronogen to fibrin
PHV, hypercoag and blood stasis
Extrinisc
tissue damage, factor 8 interacts with tissue factor- acrivates facotr 10
Fibrin foromation same in the end
Requires blood and tissue factor
Inhibitng coagulation
Protein C
Strengthended by protein S
Vitamin K
Metabolised into factor 2, 8, 9, 10
involved protein c and s synthesis
Heparin
potentiates activity of antirhombin 3
Anticoagulants
Warfarin
Dose
takes 1-6 days to kick in
if need immeditate response use heparin
Indications
PHV
Deep vein thrombosis
Pulmonary embolism
valvular heart disease
Class
Coumarins
Vitamin K antagonist
Complications
Diziness
Headache
Hameoorage
Fever
Nausea
Tranexamic mouth wash
4.8%
Irrigate sockets
fill with haemostatic agent
Bite down on gauzes soaked with TMW
Review appt 2 days later
Infection
Check healing
500mg tablet in 10ml water
Heparin
Antiplatelet
platelet agregation
Drugs
Clopidogrel
Thienopyridines
Clopidogrel
triclopidine
Aspirin