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liver: metabolic regulation (lipid (lipid metabolism (breakdown or storage…
liver: metabolic regulation
bile
bile production by hepatocytes (this is NOT concentrated bile)
pathology:
bile stasis (jaundice)
carbohydrate
glycogen = storage for glucose
converting glucose to glycogen
pathology:
hyper- or hypoglycemia
lipid
lipid metabolism (breakdown or storage of fats for energy)
remember a lipid is composed of a glycerol head and fatty acid tails
pathology:
deposition of triglyceride in liver (fatty infiltration of the liver)
the liver can make lipids using glucose
amino acid
synthesizing proteins (important:
albumin)
, including clotting factors (with assistance from
vitamin K
)
pathology:
low albumin (low BCOP) and coagulopathy (difficulty clotting = larger INR = takes more time to clot)
detoxification
first pass metabolism to ensure none of the harmful substances enter systemic circulation
degradation of estrogen
pathology:
spider angioma (on the head and neck), gynecomastia (in males due to non-breakdown of estrogen)
everything you eat
except for fat
goes through the liver (via gastric capillaries to the portal system)