Please enable JavaScript.
Coggle requires JavaScript to display documents.
microanatomy of the kidney (nephron (renal corpuscle (glomerular capsular…
microanatomy of the kidney
nephron
renal corpuscle
glomerular capsular space
glomerulus = capillary endothelium, basement membrane, podocytes
squamous epithelium of parietal layer of glomerular capsule
proximal convoluted tubules
(PCT)
fuzzy lumen due to long microvilli
directly connected to Bowman's capsule
and loop of Henle
location:
cortex
distal convoluted tubule
(DCT)
clear lumen
directly connected to loop of Henle
and
the collecting duct system
location:
cortex
loop of Henle
thin limbs
: simple squamous, few mitochondria
think ascending:
simple cubodial, no microvilli
collecting duct
principal cells
pale-staining
simple cubodial to columnar epithelium
distinct cell boundaries
rich in aquaporins
(integral membrane pore proteins that function as specific water channels)
upon binding of ADH to its receptor, aquaporins move into apical membrane to increase water absorption osmotically
intercalcated cells
fewer than principal cells
help maintain acid-base balance by secreting either H+ or HCO3-
reabsorb K+
EPO production under physiological condition
renal interstitial cells (fibroblasts)
when these fibroblasts sense hypoxia they will start producing EPO (erythropoietin) which targets bone marrow to make more RBCs