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Blood Cells-Histo (Leukocytes (Neutrophils (Function (acute inflammation,…

- - - - Granulocytes
      - 50-70%
    - - 12-15microM
    - - acute inflammation
      - phagocytosis
      - bacterial killing
      - 1-2 day lifespan
    - - Pus
      - 3-5 nuclear lobes
      - granules are neutral colored
  - - - Agranulocyte
      - 25-35%
    - - 6-8 microM when inactivated, 18microM when activated
    - - specific immune responses
        
        B & T cells employed
        
        B cells mature in Bone Marrow
        
        T cells mature in Thymus
        
        work in peripheral lymphoid system
      - viral killing
    - - large, round nucleus
        
        can be the size of a RBC
      - silver lining of cytoplasm
      - dark purple stain
      - only cell to recirculate, bloodstream to tissue and back again
  - - - Agranulocyte
      - 3-7%
    - - 12-20 microM
    - - become macrophages
      - phagocytose
      - cytokine production
      - APC
    - - very hard to ID cuz they all look so different
      - oval, horshoe, or kidney shaped nucleus
      - nucleus is lighter stained
      - cytosol can contain granules/lysosomes
  - - - Granulocyte
      - 1-3%
    - - 12-15 microM
    - - parasitic & protozoic killing
      - moderate hypersensitivity and allergic reactions
      - moderate adverse drug reactions
    - - bright pink granules
        
        Lysosomal Enzymes
        
        eosinophilic peroxidase
        
        Crystalline Cores = Major Basic Protein
      - 2-lobed nucleus
      - circulate for 3-8 hours then move on to skin, lungs, GI tract
  - - - 12-15microM
    - - like mast cells, just dump their stuff to kill
        
        leukotrine 3
        
        histamine
        
        heparin sulfate
      - inflammatory & hypersensitivity reactors
    - - Granulocyte
      - <1%
    - - tons of purple-ish granules
      - can't see nucleus
- - - - 2-4 microM in diameter
  - - - Fibrinogen
    - - serotonin
      - ATP/ADP
      - Ca2+ ions
    - - coagulation factors
- - - - women: 3.9-5.5E6/microL
      - men: 4.1-6E6/microL
  - - - flexibility
        
        fits in tight spots
      - increased surface area : volume ratio
        
        20-30% increased surface area
  - - - porphyrin ring + Fe atom
        
        Heme
      - (4) globular proteins, 1/ring
        
        Globin chains
        
        2 alpha and 2 beta globin chains
    - - Hb + O2
    - - Hb + CO2
- - - - globulins
        
        hemoglobin
      - fibrinogen
      - albumin
        
        osmotic pressure
    - - blood w/out an anti-coagulant
      - samples = clot + serum
      - no anticoagulants in liquid portion of sample
    - - buffy coat = leukocytes
        
        1%
      - Hematocrit = RBCs %
        
        42-47%
      - blood w/anticoagulant
        
        rest of it
- - - - stains pink due to acidophilic (basic) nature
      - Binds to Hemoglobin since this one is basic.