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Anesthetic Final Formulation (Factors influencing absorbtion (Physical…
Anesthetic Final Formulation
Dosage Form
Oinment (80 % oil / 20% water)
Ointments feel greasy and are “occlusive”, meaning they stay on the surface of the skin and are not well absorbed.
Creame (o/w emulsion 50:50)
They spread easily, are well absorbed, and wash off with water.
Melting points / pKa
Benzocaine 89°C / 2.5
Lidocaine: 68°C / 7.96
Tetracaine: 149 °C / 8.42
Prilocaine: 37.5°C / 7.89
Compounded formulations
TAC 20% Alternate (lidocaine 20% : tetracaine 4%)
Profound (10% lidocaine, 10% prilocaine, 4% tetracaine)
Best Topical Ever (12.5% lidocaine, 3% prilocaine, 12.5% tetracaine)
Factors influencing absorbtion
Concnetration
Duration of contact
Solubility of mediction
Physical conditions of skin
Body Parts
Mw of the molecule
Iontophoresis