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MnSOD-Mito-CAT (redox in-active mito-CAT (Supports 3-AT, MnP should rescue…
MnSOD-Mito-CAT
redox in-active mito-CAT
Supports 3-AT
MnP should rescue
Should lead to H2O2 increase with active MnSOD
Redox-inactive
Similar to WT
MnP should compensate for loss
Rescue should reduce ROS to protect against denervation
Redox inactive MnSOD
Should decrease H2O2 available for catalase to remove
MnP should restore by increasing H2O2 for CAT to remove and by metabolising H2O2
Increase
Protect against denervation
Yes
Redox dependent
Mito-ROS release
Confirm Mn porphyrins
in-active controls
Redox independent
Signalling effects
No
Fail to reduce ROS
Limited role for mitochondrial ROS
Fails to elevate redox activity compared to WT
Insufficient expression
Reaction mechanisms CAT
Complex III derived no role for matrix protection