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Anaemia (Microcytic (< 80) (↓ plasma iron
↓ ferratin
↑ TIBC (Iron…
Anaemia
Microcytic (< 80)
- ↓ plasma iron
- ↓ ferratin
- ↑ TIBC
-
- ↓ plasma iron
- ↓ ferratin
- ↓ TIBC
-
-
Normocytic (80-100)
Increased haemolysis
- corrected reticulocyte >3%
Intravascular haemolysis
- haemoglobinuria
- haemoglobinaemia
- ↓ hepatoglobin
- haemosiderinuria (kidney tubules)
- limited/no jaundice
- Paroxysmal nocturnal haemoglobinuria (PNH)
- G6PD anaemia
- Malaria
- IgM-mediated immune haemolytic anaemia (IHA)
- Microangiopathic haemolytic anaemia
Extravascular haemolysis
- hepatosplenomegaly
- jaundice
- ↑ risk bilirubin stones
- Hereditary spherocytosis
- Sickle cell anaemia
- HbC disease
- IgG-mediated immune haemolytic anaemia (IHA)
Decreased production
- corrected reticulocyte < 3%
- Early stages of micro/macrocytic anaemia
- Renal failure
- Parvovirus B19 (infects progenitor red cells)
- Aplastic anaemia (damage to HSC)
- Myelophthisic process (replacement of bone marrow)
Macrocytic (> 100)
Megaloblastic
- presence of multinucleated
(>6) neutrophils
-
-
-
Non-megaloblastic
- non-presence of multinucleated
neutrophils
- Alcohol induced
- Chronic liver disease
- Drugs
-