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COPD airflow limitation (s/s (barrel chest (due to chronic hyperinflation,…

- - - - :arrow_up: goblet cells, enlarge submucosal gland
        
        :arrow_up: secretion of mucus
        
        repeating of such leads to thickening, fibrosis, exudate in wall
  - - - alpha1 antitrypsin deficiency
        
        alpha 1 antiyrypsin is enzyme inhibitor that protect the lung
      - lung bornt more sensitive
- - - - result in :arrow_down: surface area
    - - Centrilobular (centriacinar)
        
        around bronchioles
        
        affect upper lobes, upperpart of lower lobes
      - panlobular (panacinar)
        
        distention of the entire acinus,
        
        lower half of lung
- - - - reduced FEV, force expiratory volume in 1 sec