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Immunologic Tolerance (Mechanism of Tolerance (can occur in thymus and…

- - - - Inappropriate MHC class
      - Downregulation of TCR
      - Lack of co-stimulatory signals from APCs or TH cells
        
        Lack of co-stimulation by TH2 cells leads to B cell anergy
        
        signal 1 - from antigen binding to and cross linking the BCR
        
        signal 2 - interaction of CD40L expressed on the T cell with CD40 on the B cell
        
        2 signals are required for B cell activation by a T dependent antigen
        
        absence of 2nd signal leads to failure in B cell to be activated and will be anergized
      - Downregulation of CD4/CD8
  - - - Positive - to select cells that are self-MHC restricted
      - Negative - to kill cells with specificity for self-antigen peptide with self-MHC
    - - select cells that are specific for foreign antigenic peptide plus self MHC