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PARAMOMYCIN (Pharmacokinetics. (Distribution (Not available), Metabolism…
PARAMOMYCIN
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MOA
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Bacterial proteins are synthesized by ribosomal RNA complexes which are composed of 2 subunits, a large subunit (50s) and small (30s) subunit, which forms a 70s ribosomal subunit. tRNA binds to the top of this ribosomal structure. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced. Continuous production of defective proteins eventually leads to bacterial death
Adverse effects
Diarrhea, Pruritus, Hypocholestreroalemia, Headavhe, vertigo and haematuria.
Potentially fatal : Pseudomembranous colitis, nephrotoxicity, neuromuscular blockade.
Ototoxicity, anorexia, nausea, vomiting, epigastric pain, increased GI motility,abdominal cramp.