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NEOMYCIN Neomycin-Therapeutic-uses-Dosage-Side-Effects (Clinical use…
NEOMYCIN 
Clinical use
useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter
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some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides
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Mechanism of Action
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So incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes
leads to interference with the initiation complex, misreading of mRNA
Pharmacokinetics
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Absorption
Very little is absorbed after oral administration and more than 95% is eliminated unchanged in the feces
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Adverse/Side Effect
serious allergic causes rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing
Nausea, vomiting, and diarrhea if taken oral route
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most likely of all the aminoglycosides :
damage the kidneys and the auditory branch of the eighth nerve
serious side effect : difficulty walking, numbness/tingling, muscle twitching or weakness, seizure
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