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Nitrates (Indications (Angina Pectoris, Myocardial Infarction, Congestive…
Nitrates
Drug Interactions
Nitrates + Cabergoline / Ergonovine
Slows down
metabolism of Cabergoline
&
Ergonovine
Increase in
systolic BP
Nitrates + Erectile Dysfunction Drugs
Cause excessive
BP
reduction
Adverse Effect / Side Effect
Common
Dizziness
Lightheadedness
Headache
Nausea
Flushing
Hypotension
Burning & Tingling under the tongue
Others
Skin irritation
Itching
Mechanism of Action
Dilate
coronary vessels
Redistribution of blood to
ischemic tisues
Reduce
preload
on the heart
Reduces
cardiac workload
& decreases
afterload
Indications
Angina Pectoris
Myocardial Infarction
Congestive Heart Failure
Examples of Drugs
Isosorbide dinitrate
(ISDIN)
Isosorbide mononitrate
(IMDUR)
Nitroglycerin
(DBL GLYCERYL TRINITRATE)