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Calcium Channel Blockers (Indications (Others (Pulmonary Hypertension,…
Calcium Channel Blockers
Adverse Effect / Side Effect
Dihydropyridines
Flushing
Headache
Excessive Hypotension
Edema
Reflex Tachycardia
Sexual Dysfunction
Liver Dysfunction
Non-dihydropyridines
Excessive Bradycardia
AV block
Depressed Contractility
Mechanism of Action
Inhibit the movement of
calcium ions
into cardiac muscles
Reduce
electrical conduction
within the heart
Decrease the
force of contraction
Dilate
arteries
Indications
Hypertension
Cardiac Arrhythmia
Angina Pectoris
Others
Pulmonary Hypertension
Raynaud's Disease
Migraine Prophylaxis
Classes
Dihydropyridines
Isradipine
Felodipine
Amlodipine
Nicardipine
Nifedipine
Nitrendipine
Nimodipine
Non-dihydropyridines
Diltiazem
Verapamil
Examples of Drugs
Nifedipine
(ADALAT)
Amlodipine
(NORVASC)
Felodipine
(PLENDIL)
Verapamil
(ISOPTIN)
Drug Interactions
Verapamil / Diltiazem + HMG-CoA Reductase Inhibitors
Increase the blood levels
of
HMG-CoA Reductase Inhibitors
> toxicity
Verapamil / Diltiazem + Carbamazepine
Increase the blood levels
of
Carbamazepine
> toxicity
Felodipine + Cyclosporine
Increase the level
of
Cyclosporine
> toxicity
Calcium Channel Blockers + Grapefruit juice
Elevate serum concentrations
of
Calcium Channel Blockers
.