Please enable JavaScript.

Coggle requires JavaScript to display documents.

pathogens of the neural system (invasion of muscle (Bacteria…

- - - - life cycle: lytic and latent (躲避免疫攻擊、製造低量蛋白)
      - 自帶 thymidine kinase (協助在神經細胞中複製、藥物標的)
      - nuclear membrane as outer-envelope -> 怕酒精
      - HSV-1 (三叉神經節、齦炎性口炎、唇皰疹)
      - HSV-2 (腰薦神經節、生殖器皰疹)
      - VZV (neuron、水痘、帶狀皰疹)
- - - - gas gangrene
      - alpha-toxin -> plasma membrane lysis -> cell death
      - alpha and theta toxins -> double zone (blood agar)
      - digest lecithin
    - - LL (細菌多、無免疫)
      - TT （細菌無、免疫強）
      - 空氣、飛沫傳染
      - acid-fast stain, do not grow in culture
      - Dapsone, Rifampin, Clofazamine
- - - - phage
      - block release of ACh
      - 來自血液 -> NMJ
    - - 自 PNS-> CNS (pH下降後得以作用)
      - prevent release of GABA & glycine
      - plasmid
- - - - Herpes Simple virus
      - Enterovirus (poliovirus)
      - others (paramyxovirus-mumps, rotavirus- 日本腦炎病毒, HIV)
    - - Haemophilus influenzae
        
        capsule, IgA protease, pili, endotoxin, outer membrane proteins
        
        chacolate agar, X factor (hematin), V factor (NAD)
        
        G(-)
        
        疫苗for type B
      - Neisseria meningitis
        
        chocolate agar, CO2, MTM
        
        capsule, IgA protease, pili, endotoxin, outer membrane proteins
        
        G(-)
      - Streptococcus pneumoniae
        
        G(+)
        
        capsule, IgA protease
        
        alpha-hemolysis (草綠)
        
        Quellung reaction
        
        23價疫苗
      - others (E.coli (KI type), group B streptococcus- newborn, Listeria, TB)
  - - - Rhabdovirus (Rabies)
        
        咬了之後，自muscle, peripheral n. (nicotinic ACh receptor) -> CNS -> glial cells -> neurons
        
        spasms, convulsions, hydrophobia
        
        PCR/ Biopsy (Negri bodies)
      - poliovirus (and other enterovirus)
        
        Polio Vaccine: Salk's (denatured) ; Sabin's (活的)
        
        capsid proteins (VP1-3)
        
        type 71 -> meningitis
        
        poliovirus receptor
      - others (paramyxovirus- mumps, retrovirus, HIV, slow virus- rubella, measles)
      - Herpesvirus (HSV, VZV, CMV) :
    - - 庫賈氏病、BSE、Scrapie, kuru
      - 無核酸、slow replication (潛伏15-35年)、無免疫反應
      - PrP(C) 被 PrP(SC) 帶壞的過程（在膜上）
      - alpha helix -> beta sheets
      - 比較一般virus與prion同異處