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Lymphoid Malignancies (ALL (B-lymphoblastic Leukaemia : (t(11q23;V) MLL…
Lymphoid Malignancies
ALL
B-lymphoblastic Leukaemia
:
t(11q23;V) MLL rearrangement
[P]
BCR-ABL
[P]
t(12;21)
most common
seen in ALL
TEL fused with AML1
Hyploidy <45 Ch
[P]
Hyperploidy >50 Ch
[G]
CD45+
CD10/CALLA + (Leukaemic specific)
90% of ALL is B type
Highest incidence 2-5 years of age
Mature B cell neoplasms
(CLL)
B cell CLL
Prolymphocytic Leukemia
Hairy Cell Leukaemia
Plasma Cell Neoplasms
Incidence increases with age
Immunophenotype & Cytogenetics
B-CLL
CD 5+
CD 23+
FMC 7-
Most common 13q deletion
Flow & PCR - MDR
PLL
Variant of CLL
No smear cells
FMC 7+
B cell (70%) and T cell
B cell p53
HCL