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SEROTONIN (RECEPTORS (multiple transduction mechamisms (5HT-1a…
SEROTONIN
RECEPTORS
7 receptors
6 metabotropic
activate a G protein and depending on the alpha subunit we can have different pathways
5-HT1
inhibitory
5-HT4
stimulatory
5-HT2
calcium mobilization
slower
1 ionotropic (5-HT3)
faster
opening of channels upon binding and ion flux
serotoniin acts on these receptors in a highly regulated way
COLLATERAL EFFECTS
interaction of NT with receptors other than desired
different monoamines receptors
different receptors of the same monoamine
multiple transduction mechamisms
5HT-1a
anxiety/depression
5HT-1d
migraine
5HT-2
various CNS behaviours and CV system
5HT-3
nausea and vomiting
DEPRESSION
Serotonin is the most relevant NT
caused by reduced MONOAMINES
serotonin
noradrenaline
dopamine
reduction can be externally caused by
reserpine (antihypertensive drug that induces a depletion of the synapsis)
lack of tryptophan in the diet
tryptophan
active CNS transport
tryptophan hydroxylase
5-hydroxytryptophan
enzymes
serotonin
we can act on the synthesis or on the metabolism
MAO inhibitors
lots of functions (mod regulation, aggression, appetite/satiety, CV functions, cognitive features, pain, sexual activity, endocrine regulation, GI function...)
TRANSPORTERS