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Common Virus Diseases (Chronic latent infection (Herpesvirus infection)…

- - - - Large, pink-purple, multinucleated
    - - Bilateral lip & nose
      - Intraepidermal blister, ulcer, crust
      - Pain
    - - Lymph node enlargement
      - Splenomegaly, disseminated
  - - - Primary infection in skin, mucosa
      - Skin rash 2 weeks
        after respiratory infection
      - Centrifugal distribution
      - Macule
        ➡️ Vesicle with intranuclear inclusion in epidermis
        ➡️ Crust
    - - Latent in dorsal root ganglion
        after previous chickenpox
      - Reactivation with localized recurrence in dermatone
      - Infect sensory nerve
      - Painful vesicular lesion on dermatone
        
        Trigeminal nerve
        
        Facial paralysis
        (Ramsay Hunt syndrome)
  - - - Congenital
      - Perinatal
      - Opportunistic
    - - Inclusion
        
        Intranuclear
        
        Owl eye-like
        
        Large, purple with clear halo
        
        Inteacytoplasmic
      - Asymptomatic
      - Opportunistic infection
        
        Interstitial pneumonia
        
        Sialadenitis
        
        Renal tubulitis
  - - - Neuron: latency
      - Reactivation
      - Recurrent skin/ mucosa lesion
    - - Individual cell damage
      - Little or no host inflammatory response
      - HSV: intranuclear inclusion body
      - CMV: intranuclear & cytoplasmic inclusion body
      - HPV: cervical squamous epithelium ➡️ Epithelial hyperplasia➡️ Epithelial dysplasia ➡️ Cervical carcionoma (Koilocyte)
    - - Sample sourc:
        
        blood, ascites, pleural effusion, sputum
        
        stool
        
        urine, secretions
      - Identification of infectious agents
      - Inflammatory reaction
- - - - Respiratory epithelium
      - Lymphocyte, macrophage
    - - RNA virus
      - Paramyxovirus family
    - - T-cell mediated immunity
    - - Measles rash
        
        Face, trunk, proximal extremity
        
        Chronic inflammation, dilated vessel, edema
        
        Koplik spot:
        
        ulcerated mucosa in oral cavity
        
        near opening if Stensen duct
      - Lymphoid follicular hyperplasia
        
        Warthin-Finkeldey cell:
        multinucleate giant cell with eosinophilic nuclear & cytoplasmic inclusion body
- - - - Pathologenesis
        
        Productive infection
        
        Lysis of infected cell
        
        Latent infection
        
        Latency-associated gene
        
        EBNA1: DNA replication
        
        EBNA2 & LMP-1: B cell activation & proliferation
        
        LMP-1 binding to TNF-receptor associated factor
        
        Polyclonal B cell activation & proliferation
        
        Heterophil anti-sheep RBC Ab
        
        Immunoresomse to EBV infection
        
        IgM, IgG, IgA for VCA, early Ag, EBNA
        
        Atypical lymphocyte (Ts cell)in peripheral blood:
        deceeases B cell proliferation
        
        Clinical features
        
        Fever
        
        Sore throat
        
        Skin rash
        
        Generalized lymphadenopathy
        
        Hepatosplenomegaly
        
        Splenic ruoture - fatal
        
        Liver function impairment
        
        Meningoencephalitis